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单倍体选择下的多位点动态

Multilocus dynamics under haploid selection.

作者信息

Kirzhner V, Lyubich Y

机构信息

Institute of Evolution, University of Haifa, Mount Carmel, Israel.

出版信息

J Math Biol. 1997 Mar;35(4):391-408. doi: 10.1007/s002850050058.

Abstract

A general haploid selection model with arbitrary number of multiallelic loci and arbitrary linkage distribution is considered. The population is supposed to be panmictic. A dynamically equivalent diploid selection model is introduced. There is a position effect in this model if the original haploid selection is not multiplicative. If haploid selection is additive then the fundamental theorem is established even with an estimate for the change in the mean fitness. On this basis exponential convergence to an equilibrium is proved. As rule, the limit states are single-gamete ones. If, moreover, linkage is tight, then the single-gamete state with maximal fitness attracts the population for almost all initial states.

摘要

考虑一个具有任意数量多等位基因位点和任意连锁分布的一般单倍体选择模型。假设种群是随机交配的。引入了一个动态等效的二倍体选择模型。如果原始单倍体选择不是乘法性的,那么在这个模型中存在位置效应。如果单倍体选择是加性的,那么即使对平均适应度的变化有一个估计,也能建立基本定理。在此基础上,证明了向平衡的指数收敛。通常,极限状态是单配子状态。此外,如果连锁紧密,那么具有最大适应度的单配子状态会吸引几乎所有初始状态的种群。

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