153例超声检测出胎儿异常的妊娠中染色体异常的发生率

Incidence of chromosomal abnormalities in 153 pregnancies with ultrasound detected fetal abnormalities.

作者信息

Chew S, Anandakumar C, Jayanthi V, Wong Y C, Chia D, Arulkumaran S, Ratnam S S

机构信息

Department of Obstetrics & Gynaecology, National University Hospital, Singapore.

出版信息

Singapore Med J. 1996 Dec;37(6):595-7.

PMID:9104057

Abstract

One hundred and fifty-three patients with fetal abnormalities diagnosed on ultrasound were karyotyped between January 1992 and December 1993. There were 19 (12.4%) fetuses with chromosomal abnormalities. The risk of chromosomal aberrations in the malformed fetuses were increased in the presence of intrauterine growth retardation (15.4%), oligohydramnios (20%) and polyhydramnios (25%). Fetal karyotyping is thus essential in the management of such pregnancies.

摘要

1992年1月至1993年12月期间，对153例经超声诊断为胎儿异常的患者进行了染色体核型分析。其中有19例（12.4%）胎儿存在染色体异常。在存在宫内生长迟缓（15.4%）、羊水过少（20%）和羊水过多（25%）的情况下，畸形胎儿染色体畸变的风险增加。因此，胎儿染色体核型分析在这类妊娠的管理中至关重要。