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精浆前列腺酸性磷酸酶是男性不育的可靠标志物吗?

Is seminal prostatic acid phosphatase a reliable marker for male infertility?

作者信息

Singh G, Adaikan P G, Ng Y K

机构信息

Department of Anatomy, National University of Singapore, Singapore.

出版信息

Singapore Med J. 1996 Dec;37(6):598-9.

PMID:9104058
Abstract

This project was undertaken to determine whether there is any correlation between sperm counts and motility and the level of prostatic acid phosphatase (PAcP). Fifty-six patients were studied in this series-those with normospermia (Group A,n = 19); mild oligospermia (Group B,n = 18) and very severe oligospermia (Group C,n = 19). Each group was further subdivided into 2 groups-those who were 25-35 years old and those 36 years old and above. The results in this age group are discussed and it was found that individuals with very severe oligospermia (sperm counts 1-20x10(5)/mL) showed a positive correlation (p = 0.009) in the age group 36 years and above. The results have to be treated with caution since a statistically significant result was only displayed in one group, ie, individuals over the age of 35 years and very low sperm counts.

摘要

开展该项目是为了确定精子计数和活力与前列腺酸性磷酸酶(PAcP)水平之间是否存在任何相关性。本系列研究了56名患者——精液正常者(A组,n = 19);轻度少精子症患者(B组,n = 18)和重度少精子症患者(C组,n = 19)。每组又进一步分为两组——25至35岁者和36岁及以上者。讨论了该年龄组的结果,发现重度少精子症患者(精子计数为1 - 20×10⁵/mL)在36岁及以上年龄组中呈正相关(p = 0.009)。由于仅在一组(即35岁以上且精子计数极低的个体)中显示出具有统计学意义的结果,因此对这些结果必须谨慎对待。

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引用本文的文献

1
Emerging roles of human prostatic Acid phosphatase.人前列腺酸性磷酸酶的新作用
Biomol Ther (Seoul). 2013 Jan;21(1):10-20. doi: 10.4062/biomolther.2012.095.
2
Human prostatic acid phosphatase: structure, function and regulation.人前列腺酸性磷酸酶:结构、功能与调控
Int J Mol Sci. 2013 May 21;14(5):10438-64. doi: 10.3390/ijms140510438.
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Functional proteomic analysis of seminal plasma proteins in men with various semen parameters.对不同精液参数男性精液蛋白的功能蛋白质组学分析。
Reprod Biol Endocrinol. 2013 May 11;11:38. doi: 10.1186/1477-7827-11-38.