Skurkovich S V, Ol'shanskaia N V, Kalinina I A, Klinova E G, Eremkina E I
Vopr Onkol. 1977;23(9):44-50.
The treatment of cells L-1210 and MX-11 in vitro with interferon, prior to their injection to mice, caused an enhancement of specific humoral response and cytotoxic action of immune lymphocytes to Cr51 labelled target cells. The injecting of mice with allogeneic interferon-containing serum against the background of immunization with L-1210 cells produces an enhancing effect upon the immune response. Much more marked enhancing effect was observed when using syngeneic interferon-containing serum. Short-term treatment of lymphocytes, being immune to L-1210 cells, with interferon in vitro leads to the increase of their specific cytotoxicity to Cr51 labelled cells. Pre-treatment of leukemic cells with interferon would enhance their sensitivity to specific antibodies. It is suggested to use an active immunization of acute leukemia patients with allogeneic leukemic cells pre-incubated in interferon in combination with the injection of interferon-containing donor plasma.
在将细胞L - 1210和MX - 11注射到小鼠体内之前，先在体外使用干扰素对其进行处理，可增强特异性体液反应以及免疫淋巴细胞对Cr51标记靶细胞的细胞毒性作用。在用L - 1210细胞免疫的背景下，给小鼠注射含同种异体干扰素的血清，会对免疫反应产生增强作用。当使用含同基因干扰素的血清时，观察到的增强作用更为显著。用干扰素在体外对已对L - 1210细胞产生免疫的淋巴细胞进行短期处理，会导致其对Cr51标记细胞的特异性细胞毒性增加。用干扰素对白血病细胞进行预处理会增强其对特异性抗体的敏感性。建议对急性白血病患者进行主动免疫，使用预先在干扰素中孵育的同种异体白血病细胞，并结合注射含干扰素的供体血浆。
