Peña J, Vallet-Regí M, San Román J
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, U.C.M., Madrid, Spain.
J Biomed Mater Res. 1997 Apr;35(1):129-34.
Composite hydrogels of poly(acrylic acid) (PAA) and poly-(methyl metacrylate) (PMMA) reinforced with a bioceramic, TiO2, have been prepared by reactive moulding from a mixture of the bioceramic with PMMA beads and acrylic acid. Cylindrical specimens with various TiO2-polymer compositions, but a constant 3:1 PAA/PMMA ratio were obtained, and their corresponding swelling behavior was followed at pH = 7.0 and pH = 8.0 in buffered solution at 37 degrees C. The composition and structure of the composites prepared was studied by thermogravimetry, 1H-NMR spectroscopy and scanning electron microscopy. The composites prepared present a considerable consistency, even in hydrated media, since their swelling behavior is rather sensitive to the pH of the media. Specific polar interactions of the carboxylic groups of the hydrophilic polymer component PAA with the surface of TiO2 particles, modulate the behavior of the composites against the hydration processes at different pH.
通过将生物陶瓷TiO₂与聚甲基丙烯酸甲酯（PMMA）珠粒及丙烯酸的混合物进行反应模塑，制备了用生物陶瓷TiO₂增强的聚丙烯酸（PAA）和聚甲基丙烯酸甲酯（PMMA）复合水凝胶。获得了具有不同TiO₂ - 聚合物组成但PAA/PMMA比例恒定为3:1的圆柱形试样，并在37℃的缓冲溶液中于pH = 7.0和pH = 8.0下跟踪其相应的溶胀行为。通过热重分析、¹H - NMR光谱和扫描电子显微镜研究了所制备复合材料的组成和结构。所制备的复合材料即使在水合介质中也具有相当的稠度，因为它们的溶胀行为对介质的pH相当敏感。亲水性聚合物组分PAA的羧基与TiO₂颗粒表面的特定极性相互作用，调节了复合材料在不同pH下对水合过程的行为。
