Arcos D, Cabanas M V, Ragel C V, Vallet-Regí M, San Román J
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, Madrid, Spain.
Biomaterials. 1997 Sep;18(18):1235-42. doi: 10.1016/s0142-9612(97)00054-9.
Two composite systems composed of alpha-Al2O3/poly(methyl methacrylate) (PMMA)/poly(vinyl pyrrolidone) (PVP)/ibuprofen or alpha-Al2O3/PMMA/co-vinyl pyrrolidone-methyl methacrylate/ibuprofen were prepared by free radical polymerization. These systems were characterized by spectroscopic techniques and thermogravimetric and differential thermal analyses. The hydration behaviour of composites with different hydrophilic characters was analysed after the immersion of the composites in buffered solution at pH 7.4 and 37 degrees C. The swelling of the composites depends strongly on the content of the hydrophilic component and is controlled by the presence of the ceramic component. The release of the anti-inflammatory drug, ibuprofen, from the composites in buffered solution was followed by UV spectroscopy and the results obtained indicated that the components of the composites influenced the rate of release of the drug, without the classical 'burst' effect observed frequently with hydrophilic systems.
通过自由基聚合制备了由α - 氧化铝/聚甲基丙烯酸甲酯（PMMA）/聚乙烯吡咯烷酮（PVP）/布洛芬或α - 氧化铝/PMMA/乙烯基吡咯烷酮 - 甲基丙烯酸甲酯共聚物/布洛芬组成的两种复合体系。采用光谱技术、热重分析和差示热分析对这些体系进行了表征。将复合材料浸泡在pH值为7.4、温度为37℃的缓冲溶液中后，分析了具有不同亲水性的复合材料的水化行为。复合材料的溶胀强烈依赖于亲水组分的含量，并受陶瓷组分的存在控制。通过紫外光谱跟踪缓冲溶液中复合材料中抗炎药物布洛芬的释放情况，所得结果表明复合材料的组分影响药物的释放速率，且未观察到亲水体系中常见的经典“突释”效应。
