Hori R, Kohno S, Hoshino E
Department of Removable Prosthodontics, Niigata University School of Dentistry, Japan.
J Prosthet Dent. 1997 Apr;77(4):348-52. doi: 10.1016/s0022-3913(97)70157-4.
The aim of this study was to observe the antibacterial potential of polycarboxylate temporary cement containing a mixture of metronidazole, ciprofloxacin, and cefaclor on carious lesions of prepared abutments that were designed to leave caries on the abutments.
Antibacterial efficacy was estimated in vitro and in vivo by measuring bacterial recovery from the lesions. Bacteria counts ranged from 10(4) to 10(7) both in vitro (nine samples) and in vivo (five samples) in time-zero samples, just before the application of the antibacterial cement.
No bacteria were recovered from carious lesions in vitro (six samples) or in vivo (four samples) after the lesions were covered by the antibacterial temporary cement. For the remaining samples, some bacteria (5 to 80 counts per sample) were recovered, with one notable exception in which marginal leakage provided a bacteria count of 10(3). Bacteria counts ranging from 10(3) to 10(5) occurred in carious lesions covered by temporary cement without antibacterial agents, which indicated that temporary cement alone was not a potent disinfectant.
The results of this study indicated that the antibacterial temporary cement can be useful for eradicating bacteria from carious lesions of prepared abutments.
本研究旨在观察含甲硝唑、环丙沙星和头孢克洛混合物的聚羧酸锌水门汀对预备基牙龋损的抗菌潜力,这些预备基牙设计为保留龋坏。
通过测量从龋损处回收的细菌数量,在体外和体内评估抗菌效果。在应用抗菌水门汀之前的零时样本中,体外(9个样本)和体内(5个样本)的细菌计数范围为10⁴至10⁷。
用抗菌水门汀覆盖龋损后,体外(6个样本)或体内(4个样本)的龋损处均未回收细菌。对于其余样本,回收了一些细菌(每个样本5至80个菌落计数),有一个显著例外,即边缘渗漏导致细菌计数为10³。在未含抗菌剂的水门汀覆盖的龋损处,细菌计数范围为10³至10⁵,这表明单独的水门汀不是有效的消毒剂。
本研究结果表明,抗菌水门汀可用于清除预备基牙龋损处的细菌。