Endometrial biopsy.

Endometrial biopsy is an important diagnostic tool for the evaluation of infertility and abnormal uterine bleeding. The documented safety and accuracy of the plastic endometrial sampling devices have made them popular for use in the office. The procedure requires limited equipment and supplies, and it is generally well tolerated without anesthesia. The pathology report can guide the treatment of benign lesions, including simple hyperplasia. The finding of cytologic atypia indicates a significant risk of progression to carcinoma, and hysterectomy should be considered. If symptoms persist despite a normal endometrial biopsy, further evaluation is recommended.