al-Suhaili A R, Sztriha L, Prais V, Nork M
Department of Nuclear Medicine, Tawam Hospital, Al Ain, United Arab Emirates.
Brain Dev. 1997 Mar;19(2):138-43. doi: 10.1016/s0387-7604(96)00481-0.
Cerebral perfusion was investigated in three patients with agyria-pachygyria by using 99mTc-HMPAO SPECT in order to study the distribution of blood flow. Diffuse cortical hypoperfusion was found in all three infants. The visual cortex was not identifiable in two of the cases. The basal ganglia and cerebellum were prominent by their normal high activity, while tracer uptake was very low in the thalamus. The possible role of improper development of interneuronal connections and abnormal vascular pattern in background of the perfusion defect is discussed.
为研究血流分布，采用99m锝-六甲基丙二胺肟单光子发射计算机断层扫描（99mTc-HMPAO SPECT）对3例无脑回-巨脑回畸形患者的脑灌注情况进行了研究。所有3例婴儿均发现弥漫性皮质灌注不足。其中2例未发现视觉皮质。基底神经节和小脑因正常的高活性而显影明显，而丘脑的示踪剂摄取非常低。文中讨论了神经元间连接发育异常和血管模式异常在灌注缺损背景下可能发挥的作用。
