Riekkinen P, Schmidt B, Riekkinen M
Department of Neuroscience and Neurology, University of Kuopio, Finland.
Eur J Pharmacol. 1997 Mar 26;323(1):11-9. doi: 10.1016/s0014-2999(97)00016-2.
We investigated the effects of acute oral pretraining treatment with an indirect acetylcholinesterase inhibitor, metrifonate, on water maze spatial navigation in medial septum-lesioned rats. We observed that metrifonate (30 mg/kg, orally) (1) does not alter the pattern of exploration of lesioned rats at the water maze pool or retrieval of spatial memory, (2) effectively reverses the acquisition defect, (3) enhances reversal learning, and (4) improves acquisition of water maze navigation by facilitating the encoding of the spatial representation of a specific environment. These results indicate that metrifonate does not improve escape performance to the hidden platform by modulating exploration strategy, but that metrifonate enhances the speed and accuracy of development and durability of spatial memory engrams, and facilitates learning capacity that depends on activity of the septo-hippocampal projection.
我们研究了用间接乙酰胆碱酯酶抑制剂美曲膦酯进行急性口服预训练处理对内侧隔区损伤大鼠水迷宫空间导航的影响。我们观察到，美曲膦酯（30毫克/千克，口服）：（1）不会改变损伤大鼠在水迷宫水池中的探索模式或空间记忆的提取；（2）有效逆转习得缺陷；（3）增强逆向学习能力；（4）通过促进对特定环境空间表征的编码来改善水迷宫导航的习得。这些结果表明，美曲膦酯并非通过调节探索策略来提高对隐藏平台的逃避表现，而是增强了空间记忆印记形成、发展和持久的速度与准确性，并促进了依赖隔-海马投射活动的学习能力。
