Moller B B, Jensen J, Nielsen I L
Acta Med Scand. 1977;202(3):149-52. doi: 10.1111/j.0954-6820.1977.tb16803.x.
Seventeen consecutive patients subjected to jejunoileostomy for obesity have been investigated for complement abnormalities and cryoglobulinaemia. The study took place 1-9 1/2 years after the operation. A concomitant clinical examination revealed recurrent arthritis in 6 (30%) of the patients. In 6 of the patients complement abnormalities were found, as activation of the classical pathway in 3 and activation of the alternative pathway in another 3 could be suspected from immunochemical data. One patient showed activation of both the classical and the alternative pathway. Two of the patients with arthritic symptoms belonged to the group showing activation of the alternative pathway. It is suggested that deficient inactivation of bacterial products from intestinal bacteria (lipopolysaccharides) have a role in the complement abnormalities found. No patient exhibited the cryoprotein complexes found earlier in this type of patients.
对17例因肥胖接受空肠回肠吻合术的连续患者进行了补体异常和冷球蛋白血症的调查。该研究在术后1至9年半进行。同时进行的临床检查发现6例（30%）患者有复发性关节炎。6例患者发现补体异常，根据免疫化学数据怀疑3例患者经典途径激活，另3例患者替代途径激活。1例患者经典途径和替代途径均激活。2例有关节炎症状的患者属于替代途径激活组。提示肠道细菌（脂多糖）产生的细菌产物失活不足在发现的补体异常中起作用。没有患者表现出此前在这类患者中发现的冷蛋白复合物。
