Utsinger P D
J Am Acad Dermatol. 1980 Jun;2(6):488-95. doi: 10.1016/s0190-9622(80)80149-6.
Twenty-one patients with arthritis and dermatitis following intestinal bypass surgery were studied. The arthritis was polyarticular, remittent, and intermittent. Typically, the synovial fluid was inflammatory. The commonest inflammatory skin lesion was a vesiculopustular dermatitis. Nineteen patients and serum immmune complexes using the Raji cell technic. Seventeen patients had serum cryoproteins, primarily consisting of IgG 1, IgG 3, C3, and C4. Three patients had both Escherichia coli antigens and anti-E. coli antibody in their cryoprotein. Five patients had granular and one had linear deposits of immunoglobulin and complement at the dermoepidermal junction. Further evidence that bacterial antigens play a role in tissue injury was provided by detection of granular deposits of E. coli antigen at the dermoepidermal junctions in two patients, and at the glomerular capillary basement membrane in one patient.
对21例肠道搭桥术后出现关节炎和皮炎的患者进行了研究。关节炎为多关节性、缓解性和间歇性。典型情况下，滑液具有炎症性。最常见的炎症性皮肤病变是水疱脓疱性皮炎。19例患者使用Raji细胞技术检测血清免疫复合物。17例患者有血清冷球蛋白，主要由IgG 1、IgG 3、C3和C4组成。3例患者的冷球蛋白中既有大肠杆菌抗原又有抗大肠杆菌抗体。5例患者在真皮表皮交界处有颗粒状沉积物，1例有免疫球蛋白和补体的线状沉积物。在两名患者的真皮表皮交界处以及一名患者的肾小球毛细血管基底膜处检测到大肠杆菌抗原的颗粒状沉积物，这进一步证明了细菌抗原在组织损伤中起作用。
