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Methylenetetrahydrofolate reductase thermolabile variant and human longevity.

作者信息

Faure-Delanef L, Quéré I, Chassé J F, Guerassimenko O, Lesaulnier M, Bellet H, Zittoun J, Kamoun P, Cohen D

出版信息

Am J Hum Genet. 1997 Apr;60(4):999-1001.

PMID:9106548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1712461/
Abstract
摘要

相似文献

1
Methylenetetrahydrofolate reductase thermolabile variant and human longevity.亚甲基四氢叶酸还原酶热不稳定变体与人类长寿
Am J Hum Genet. 1997 Apr;60(4):999-1001.
2
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.叶酸状态、亚甲基四氢叶酸还原酶常见突变与血浆同型半胱氨酸浓度之间的关系。
Circulation. 1996 Jan 1;93(1):7-9. doi: 10.1161/01.cir.93.1.7.
3
Serum homocysteine, folate and thermolabile variant of MTHFR in healthy Sri Lankans living in London.居住在伦敦的健康斯里兰卡人的血清同型半胱氨酸、叶酸和亚甲基四氢叶酸还原酶的不耐热变体
Atherosclerosis. 2000 Mar;149(1):221-2. doi: 10.1016/s0021-9150(99)00420-7.
4
Reduced frequency of the thermolabile methylenetetrahydrofolate reductase genotype in the elderly.老年人中热不稳定亚甲基四氢叶酸还原酶基因型的频率降低。
Atherosclerosis. 1999 Oct;146(2):395-7. doi: 10.1016/s0021-9150(99)00143-4.
5
Homozygous thermolabile methylenetetrahydrofolate reductase in schizophrenia-like psychosis.精神分裂症样精神病中的纯合子热不稳定亚甲基四氢叶酸还原酶
J Neural Transm (Vienna). 1997;104(8-9):931-41. doi: 10.1007/BF01285561.
6
The frequency of the methylenetetrahydrofolate reductase-gene mutation varies with age in the normal population.在正常人群中，亚甲基四氢叶酸还原酶基因突变的频率随年龄而变化。
Am J Hum Genet. 1997 Dec;61(6):1459-60. doi: 10.1086/301640.
7
Effects of folic acid on homocysteine in persons classified by methylenetetrahydrofolate reductase genotype.根据亚甲基四氢叶酸还原酶基因型分类的人群中叶酸对同型半胱氨酸的影响。
Am J Clin Nutr. 1999 Jun;69(6):1287-9. doi: 10.1093/ajcn/69.6.1287.
8
The relationship between MTHFR genotype, serum homocysteine and folate levels.亚甲基四氢叶酸还原酶（MTHFR）基因型、血清同型半胱氨酸和叶酸水平之间的关系。
Biochem Soc Trans. 1997 Aug;25(3):386S. doi: 10.1042/bst025386s.
9
[Homocysteine, methylenetetrahydrofolate reductase/C677T genotype and risk for coronary heart disease. The AtheroGene study].
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10
Hyperhomocysteinemia, MTHFR C677T genotype and low folate levels: a risk combination for acute coronary disease in a Portuguese population.
Thromb Haemost. 2000 Mar;83(3):517-8.

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Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice.晚年饮食中叶酸限制可减少生物合成过程，且不影响小鼠的健康寿命。
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Lack of association between the MTHFR C677T variant and migraine with aura in an older population: could selective survival play a role?在老年人群中，MTHFR C677T 变体与有先兆偏头痛之间缺乏关联：选择性存活是否起作用？
Cephalalgia. 2013 Apr;33(5):308-15. doi: 10.1177/0333102412469739. Epub 2012 Dec 10.
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Genetic selection? A study of individual variation in the enzymes of folate metabolism.遗传选择？叶酸代谢酶个体变异的研究。
BMC Med Genet. 2010 Feb 1;11:18. doi: 10.1186/1471-2350-11-18.
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Relations between molecular and biological abnormalities in 11 families from siblings affected with methylenetetrahydrofolate reductase deficiency.来自受亚甲基四氢叶酸还原酶缺乏影响的兄弟姐妹的11个家庭中分子与生物学异常之间的关系。
Eur J Pediatr. 2003 Jul;162(7-8):466-475. doi: 10.1007/s00431-003-1196-9. Epub 2003 May 6.
9
Impact of new mutations in the methylenetetrahydrofolate reductase gene assessed on biochemical phenotypes: a familial study.基于生化表型评估亚甲基四氢叶酸还原酶基因新突变的影响：一项家族研究。
J Inherit Metab Dis. 2001 Dec;24(8):833-42. doi: 10.1023/a:1013988123902.
10
A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability.亚甲基四氢叶酸还原酶基因的多态性易导致具有微卫星不稳定性的结直肠癌。
Gut. 2002 Apr;50(4):520-4. doi: 10.1136/gut.50.4.520.

本文引用的文献

1
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.叶酸状态、亚甲基四氢叶酸还原酶常见突变与血浆同型半胱氨酸浓度之间的关系。
Circulation. 1996 Jan 1;93(1):7-9. doi: 10.1161/01.cir.93.1.7.
2
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.轻度高同型半胱氨酸血症的分子遗传学分析：亚甲基四氢叶酸还原酶基因中的常见突变是心血管疾病的遗传风险因素。
Am J Hum Genet. 1996 Jan;58(1):35-41.
3
Genetic associations with human longevity at the APOE and ACE loci.载脂蛋白E（APOE）和血管紧张素转换酶（ACE）基因座与人类长寿的遗传关联。
Nat Genet. 1994 Jan;6(1):29-32. doi: 10.1038/ng0194-29.
4
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population.维生素状态和摄入量作为老年人群高同型半胱氨酸血症的主要决定因素。
JAMA. 1993 Dec 8;270(22):2693-8. doi: 10.1001/jama.1993.03510220049033.
5
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.热不稳定型5,10-亚甲基四氢叶酸还原酶作为轻度高同型半胱氨酸血症的一个病因
Am J Hum Genet. 1995 Jan;56(1):142-50.
6
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase.一种血管疾病的潜在遗传风险因素：亚甲基四氢叶酸还原酶的常见突变
Nat Genet. 1995 May;10(1):111-3. doi: 10.1038/ng0595-111.
7
Folic acid--an innocuous means to reduce plasma homocysteine.叶酸——一种降低血浆同型半胱氨酸的无害方法。
Scand J Clin Lab Invest. 1988 May;48(3):215-21. doi: 10.3109/00365518809167487.
8
Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.热不稳定亚甲基四氢叶酸还原酶：冠状动脉疾病的一种遗传风险因素。
Am J Hum Genet. 1991 Mar;48(3):536-45.
9
A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians.
JAMA. 1992 Aug 19;268(7):877-81.