https://ror.org/01f5ytq51 Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
https://ror.org/01f5ytq51 Department of Microbial Pathogenesis and Immunology, School of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA.
Life Sci Alliance. 2024 Jul 23;7(10). doi: 10.26508/lsa.202402868. Print 2024 Oct.
Folate is a vitamin required for cell growth and is present in fortified foods in the form of folic acid to prevent congenital abnormalities. The impact of low-folate status on life-long health is poorly understood. We found that limiting folate levels with the folate antagonist methotrexate increased the lifespan of yeast and worms. We then restricted folate intake in aged mice and measured various health metrics, metabolites, and gene expression signatures. Limiting folate intake decreased anabolic biosynthetic processes in mice and enhanced metabolic plasticity. Despite reduced serum folate levels in mice with limited folic acid intake, these animals maintained their weight and adiposity late in life, and we did not observe adverse health outcomes. These results argue that the effectiveness of folate dietary interventions may vary depending on an individual's age and sex. A higher folate intake is advantageous during the early stages of life to support cell divisions needed for proper development. However, a lower folate intake later in life may result in healthier aging.
叶酸是细胞生长所必需的维生素，以叶酸的形式存在于强化食品中，以预防先天畸形。低叶酸状态对终身健康的影响尚不清楚。我们发现，用叶酸拮抗剂甲氨蝶呤限制叶酸水平可以延长酵母和蠕虫的寿命。然后，我们限制了老年小鼠的叶酸摄入，并测量了各种健康指标、代谢物和基因表达特征。限制叶酸摄入减少了小鼠的合成代谢生物合成过程，并增强了代谢可塑性。尽管限制叶酸摄入的小鼠血清叶酸水平降低，但这些动物在生命后期保持体重和肥胖，我们没有观察到不良的健康结果。这些结果表明，叶酸饮食干预的有效性可能取决于个体的年龄和性别。在生命的早期，较高的叶酸摄入有利于支持适当发育所需的细胞分裂。然而，晚年较低的叶酸摄入可能会导致更健康的衰老。
