Rodrigus P, De Winter K, Venselaar J L, Leers W H
Department of Radiotherapy, Dr. Bernard Verbeeten Instituut, Tilburg, The Netherlands.
Radiother Oncol. 1997 Feb;42(2):137-41. doi: 10.1016/s0167-8140(96)01852-x.
A retrospective analysis of late complications for patients with cervical cancer treated with two different brachytherapy schedules in one institute, using the French-Italian glossary.
From 1979 until 1986, a total of 77 patients were treated with external radiation followed by two intracavitary applications with the Gynatron Cs-137 afterloading (dose rate 0.54 Gy/h). After 1986, 66 patients received intracavitary applications with Selectron-LDR (dose rate 1.07 Gy/h). Because of the expected increase in complications with increasing dose rate, the dose per application was reduced from 25 Gy to 20 Gy.
49/77 late gastrointestinal and urinary complications were scored in the Gynatron group and 46/68 in the Selectron group. Actuarial estimates at 5 years showed 42% and 54.1% late gastrointestinal complications and 16.9% and 24.1% for late urinary complications in the patients treated with, respectively, the Gynatron and Selectron.
Despite the dose reduction, there remains a clear dose rate influence on the late morbidity. Correction for this influence is essential.
使用法意语词汇表，对一所机构中接受两种不同近距离放射治疗方案的宫颈癌患者的晚期并发症进行回顾性分析。
1979年至1986年期间，共有77例患者接受了外照射，随后使用Gynatron Cs-137后装进行两次腔内照射（剂量率0.54 Gy/h）。1986年之后，66例患者接受了Selectron-LDR腔内照射（剂量率1.07 Gy/h）。由于预计随着剂量率增加并发症会增多，每次照射剂量从25 Gy降至20 Gy。
Gynatron组有49/77例出现晚期胃肠道和泌尿系统并发症，Selectron组有46/68例出现此类并发症。5年精算估计显示，接受Gynatron和Selectron治疗的患者中，晚期胃肠道并发症分别为42%和54.1%，晚期泌尿系统并发症分别为16.9%和24.1%。
尽管剂量降低，但剂量率对晚期发病率仍有明显影响。校正这种影响至关重要。
