Ablin R J, Stein-Werblowsky R
Innapharma Inc., Upper Saddle River, New Jersey 07458-1935, USA.
Immunol Cell Biol. 1997 Apr;75(2):181-3. doi: 10.1038/icb.1997.25.
An increase in epidermoid anal cancer has been observed in the past 30 years (1959-89). This increase in anal cancer has been noted to be more pronounced in women than men. The absence of a significant interactive effect of the HIV and human papillomaviruses and the incidence of anal cancer has been noted in some studies. These observations provide the rationale for consideration of other aetiologic agents that may contribute to the increase of anal cancer in men and women. Within the context of their ability to serve as cancer initiating and promoting factors, spermatozoa and seminal plasma are suggested as aetiologic agents and/or cofactors which are common to men and women practising anal intercourse in whom an increase in anal cancer has been observed. It is further suggested that sexual behaviour, that is, anal intercourse, not sexual preference, is one of the primary factors in the development of anal cancer.
在过去30年（1959 - 1989年）中，已观察到肛管表皮样癌有所增加。据指出，肛管癌的这种增加在女性中比男性更为明显。一些研究指出，人类免疫缺陷病毒（HIV）与人乳头瘤病毒不存在显著的交互作用以及肛管癌的发病率。这些观察结果为考虑其他可能导致男性和女性肛管癌增加的病因提供了理论依据。鉴于精子和精浆作为癌症启动和促进因素的能力，它们被认为是病因和/或辅助因素，在进行肛交的男性和女性中较为常见，而这些人群中已观察到肛管癌有所增加。进一步表明，性行为，即肛交，而非性取向，是肛管癌发生的主要因素之一。
