Hutchison W D, Lozano A M, Tasker R R, Lang A E, Dostrovsky J O
Division of Neurosurgery, The Toronto Hospital (Western Division), Ontario, Canada.
Exp Brain Res. 1997 Mar;113(3):557-63. doi: 10.1007/pl00005606.
Many previous studies have demonstrated the existence of neurons with tremor-frequency activity ("tremor cells") in the thalamus of Parkinson's disease (PD) patients and these neurons are presumed to play a role in the pathogenesis of tremor. Since a major input to motor thalamus (Voa and Vop) is from the internal segment of the globus pallidus (GPi), neurons with tremor-frequency activity in motor thalamus may receive input from neurons in GPi. The aim of this study was to quantify the characteristics of tremor cells in human globus pallidus. In three PD patients with tremor undergoing microelectrode exploration of the globus pallidus prior to pallidotomy, 228 neurons were sampled, and 28 (12.3%) were identified to fire at the same frequency as the tremor. These "tremor cells" were located in the ventral portion of GPi. Autocorrelogram analysis of the sampled spike trains of these 28 tremor cells was carried out over sequential 10-s time segments, and autocorrelograms showing maximal oscillatory activity were graded from 0 to 10. Average tremor cell oscillation grades ranged from 6.8 to 7.8, similar to those reported in the MPTP-induced primate model of parkinsonism. The average tremor cell oscillation grade varied between patients, as did the clinical measures of tremor severity. Tremor cells had oscillations in spike discharges at the same average frequency (4.2-5.2 Hz) as the patient's tremor determined from the electromyogram and accelerometry records of one or more limbs (4.0-5.4 Hz), and the individual values were correlated (r2=0.73) over the total range (3.7-5.6 Hz). The results of this study demonstrate the presence of neurons with 4-6 Hz tremor-frequency activity in GPi, supporting a role of the globus pallidus in the production of rest tremor in PD patients.
许多先前的研究已证实帕金森病（PD）患者丘脑存在具有震颤频率活动的神经元（“震颤细胞”），并且推测这些神经元在震颤的发病机制中起作用。由于运动丘脑（Voa和Vop）的主要输入来自苍白球内侧部（GPi），运动丘脑中具有震颤频率活动的神经元可能接收来自GPi神经元的输入。本研究的目的是量化人类苍白球中震颤细胞的特征。在3例患有震颤的PD患者在苍白球切开术前接受苍白球微电极探查时，采集了228个神经元，其中28个（12.3%）被确定以与震颤相同的频率放电。这些“震颤细胞”位于GPi的腹侧部分。对这28个震颤细胞的采样尖峰序列在连续的10秒时间段内进行自相关图分析，显示最大振荡活动的自相关图从0到10分级。震颤细胞的平均振荡等级范围为6.8至7.8，与MPTP诱导的帕金森病灵长类动物模型中报道的相似。震颤细胞的平均振荡等级在患者之间有所不同，震颤严重程度的临床测量指标也是如此。震颤细胞的尖峰放电振荡频率与通过一个或多个肢体的肌电图和加速度计记录确定的患者震颤平均频率（4.2 - 5.2 Hz）相同（4.0 - 5.4 Hz），并且在整个范围（3.7 - 5.6 Hz）内个体值具有相关性（r2 = 0.73）。本研究结果表明GPi中存在具有4 - 6 Hz震颤频率活动的神经元，支持苍白球在PD患者静止性震颤产生中的作用。
