Da Villa G, Andjaparidze A, Cauletti M, Franco E, Roggendorf M, Sepe A, Zaratti L
Italian Institute for Prevention of Liver Diseases, Naples, Italy.
Res Virol. 1997 Mar-Apr;148(2):115-7. doi: 10.1016/s0923-2516(97)89894-9.
A seroepidemiological study of the prevalence of markers related to the most common forms of viral hepatitis was carried out in Bhutan on 1,666 healthy people of both sexes, from the general population. A group of 440 pregnant women were screened separately. Our results suggest that in Bhutan, hepatitis A and hepatitis B are widespread, while there is a low prevalence of hepatitis C and E. Anti-HAV (anti-hepatitis A virus) was found in all 171 tested subjects over 12 years of age, and anti-HBc (anti-hepatitis B core antigen) in 63.1% of 1,666 tested people. On the other hand, anti-HEV proved positive in 2.0% of 257 tested subjects, and anti-HCV in only 1.3% of 611 tested subjects. Hepatitis B surface antigen (HBsAg) was found in 5.9% of the sample from the general population (5.2% in children, 5.6% in young people and 6.3% in adults) and in 5.4% of the pregnant women. Furthermore, 29.1% of HBsAg-positive pregnant women were HBeAg- and HBV DNA-positive, too. Comparing the pregnant women's prevalence data to those found in children, we suggest that the main route of HBV transmission in the Bhutanese population is vertical, from mother to child; this finding is important for the implementation of a correct anti-HBV vaccination strategy in Bhutan.
在不丹，对1666名来自普通人群的健康男女进行了一项血清流行病学研究，以调查与最常见病毒性肝炎形式相关标志物的流行情况。另外对440名孕妇进行了单独筛查。我们的研究结果表明，在不丹，甲型肝炎和乙型肝炎广泛流行，而丙型肝炎和戊型肝炎的流行率较低。在所有171名12岁以上的受试对象中均检测到抗甲型肝炎病毒（抗-HAV），在1666名受试人员中有63.1%检测到抗乙型肝炎核心抗原（抗-HBc）。另一方面，在257名受试对象中有2.0%的抗戊型肝炎病毒检测呈阳性，在611名受试对象中只有1.3%的抗丙型肝炎病毒检测呈阳性。在普通人群样本中，5.9%的人检测到乙型肝炎表面抗原（HBsAg）（儿童中为5.2%，年轻人中为5.6%，成年人中为6.3%），孕妇中的这一比例为5.4%。此外，29.1%的HBsAg阳性孕妇同时也是HBeAg和HBV DNA阳性。将孕妇的流行率数据与儿童中的数据进行比较后，我们认为不丹人群中HBV传播的主要途径是垂直传播，即从母亲传给孩子；这一发现对于在不丹实施正确的抗HBV疫苗接种策略具有重要意义。
