Ndumbe P M, Skalsky J, Joller-Jemelka H I
Faculty of Medicine and Biomedical Sciences, University of Yaounde I. Cameroon.
APMIS. 1994 Sep;102(9):662-6. doi: 10.1111/j.1699-0463.1994.tb05217.x.
Since some hepatitis viruses and the human immunodeficiency viruses share common modes of transmission, such as the sexual route, we undertook to investigate the prevalence of antibodies to these and other pathogens among 384 rural pregnant women. Our study was intended to form the basis of infection management policies in pregnancy. Antibodies and other markers of the hepatitis A, B, C, and D viruses (HAV, HBV, HCV, HDV), the human immunodeficiency virus type 1 (HIV-1) and Treponema pallidum were sought. We tested for antibodies to the viruses using the appropriate enzyme-linked immunosorbent assays. HCV and HIV-1 infection were confirmed using standard immunoblotting techniques. Regarding HBV, we tested for the surface antigen (HBsAg), antibody to the surface antigen (anti-HBs) and antibody to the core antigen (anti-HBc). A non-specific test, the rapid plasma reagin test (RPR), was used for estimating Treponema pallidum (syphilis) infection. We found an overall prevalence of antibodies to HAV of 91.4%, to HCV of 6.8%, to HDV of 0%, and to HIV-1 of 3.5%. We found no IgM antibodies to HAV. The incidence of HBV markers was as follows: 5.4% for HBsAg, 61.3% for anti-HBs, and 84.6% for anti-HBc. RPR reactivity was found in 15.8% of the women. These results will be used to establish appropriate management and preventative policies for women attending the antenatal clinic. Prevention and appropriate early treatment of infections in these women will be considered.
由于一些肝炎病毒和人类免疫缺陷病毒具有共同的传播途径，如性传播途径，我们对384名农村孕妇进行了调查，以了解这些病毒及其他病原体抗体的流行情况。我们的研究旨在为孕期感染管理政策奠定基础。我们检测了甲型、乙型、丙型和丁型肝炎病毒（HAV、HBV、HCV、HDV）、1型人类免疫缺陷病毒（HIV-1）和梅毒螺旋体的抗体及其他标志物。我们使用适当的酶联免疫吸附试验检测病毒抗体。使用标准免疫印迹技术确认HCV和HIV-1感染。对于HBV，我们检测了表面抗原（HBsAg）、表面抗原抗体（抗-HBs）和核心抗原抗体（抗-HBc）。采用非特异性检测方法——快速血浆反应素试验（RPR）来评估梅毒螺旋体（梅毒）感染情况。我们发现，HAV抗体的总体流行率为91.4%，HCV抗体为6.8%，HDV抗体为0%，HIV-1抗体为3.5%。我们未发现抗HAV IgM抗体。HBV标志物的发生率如下：HBsAg为5.4%，抗-HBs为61.3%，抗-HBc为84.6%。15.8%的女性RPR反应呈阳性。这些结果将用于为产前门诊的女性制定适当的管理和预防政策。我们将考虑对这些女性进行感染的预防和适当的早期治疗。
