西奥多·R·伍德沃德奖。生长激素分泌随年龄的下降：临床意义及潜在可逆性。
Theodore R. Woodward Award. Age-related decline in growth hormone secretion: clinical significance and potential reversibility.
作者信息
Thorner M O
机构信息
Department of Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
出版信息
Trans Am Clin Climatol Assoc. 1997;108:99-105; discussion 105-8.
Abstract
Acute and chronic stimulation of GH secretion occurred after administration of MK-677 in normal elderly subjects and IGF-I was increased during four weeks of treatment. The activation of the GH/ IGF-I axis was achieved without adversely affecting ACTH, cortisol or prolactin secretion.
摘要
在正常老年受试者中给予MK-677后，生长激素（GH）分泌出现急性和慢性刺激，且在四周治疗期间胰岛素样生长因子-I（IGF-I）增加。实现了GH/IGF-I轴的激活，而未对促肾上腺皮质激素（ACTH）、皮质醇或催乳素分泌产生不利影响。
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本文引用的文献
1
Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.在健康老年受试者中，每日口服生长激素促分泌素（MK-677）对生长激素（GH）-胰岛素样生长因子I轴的刺激作用。
J Clin Endocrinol Metab. 1996 Dec;81(12):4249-57. doi: 10.1210/jcem.81.12.8954023.
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A receptor in pituitary and hypothalamus that functions in growth hormone release.一种存在于垂体和下丘脑的受体，在生长激素释放过程中发挥作用。
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Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men.
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