抗雌激素他莫昔芬对3,2'-二甲基-4-氨基联苯和睾酮诱导的大鼠前列腺癌发生的影响并不支持雌激素在睾酮促进作用中的角色。
Effects of tamoxifen, an antiestrogen, on rat prostate carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl and testosterone do not support an estrogen role in testosterone promotion.
作者信息
Miyata E, Kawabe M, Sano M, Takesada Y, Takahashi S, Shirai T
机构信息
First Department of Pathology, Nagoya City University Medical School, Japan.
出版信息
Prostate. 1997 Apr 1;31(1):9-13. doi: 10.1002/(sici)1097-0045(19970401)31:1<9::aid-pros2>3.0.co;2-k.
BACKGROUND
Our previous data suggest that estrogen plays an important role in rat prostate carcinogenesis, particularly in promotion by testosterone. Therefore, in the present experiment, effects of an antiestrogen, tamoxifen (TAM), were investigated.
METHODS
Male F344 rats initially received 3,2'-dimethyl-4-aminobiphenyl (DMAB) at 50 mg/kg bw every 2 weeks for 20 weeks and then TAM in Silastic tubes was subcutaneously given alone or together with testosterone propionate (TP) for 40 weeks.
RESULTS
TAM significantly suppressed prostate weights, suggesting an estrogenic action, but the development of preneoplastic and/or neoplastic lesions of the prostate or seminal vesicles in rats given DMAB alone or DMAB and TP was not altered. TAM reversed the suppression of development of ventral atypical hyperplasias by TP.
CONCLUSIONS
These findings suggest that estrogen, which is derived from testosterone by the action of aromatase, is not involved in the strong promotion by TP of DMAB prostate carcinogenesis.
背景
我们之前的数据表明，雌激素在大鼠前列腺癌发生过程中发挥重要作用，尤其是在睾酮的促癌作用方面。因此，在本实验中，我们研究了抗雌激素药物他莫昔芬（TAM）的作用。
方法
雄性F344大鼠最初每2周接受一次50mg/kg体重的3,2'-二甲基-4-氨基联苯（DMAB），共20周，然后将含TAM的硅橡胶管皮下植入，单独给药或与丙酸睾酮（TP）联合给药40周。
结果
TAM显著抑制前列腺重量，提示其具有雌激素样作用，但单独给予DMAB或给予DMAB和TP的大鼠前列腺或精囊的癌前和/或肿瘤性病变的发展未发生改变。TAM逆转了TP对腹侧非典型增生发展的抑制作用。
结论
这些发现表明，由芳香化酶作用将睾酮转化而来的雌激素，不参与TP对DMAB诱导的前列腺癌的强烈促癌作用。
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