局部用酮咯酸和双氯芬酸对正常角膜感觉的影响。

Effects of topical ketorolac and diclofenac on normal corneal sensation.

作者信息

Sun R, Gimbel H V

机构信息

Gimbel Eye Center, Calgary, Alberta, Canada.

出版信息

J Refract Surg. 1997 Mar-Apr;13(2):158-61. doi: 10.3928/1081-597X-19970301-12.

DOI:10.3928/1081-597X-19970301-12

PMID:9109072

Abstract

BACKGROUND

A randomized, double-masked study was conducted to investigate the effects of 0.5% ketorolac tromethamine (Acular) and 0.1% diclofenac sodium (Voltaren) on normal human corneal sensation.

METHODS

Thirty normal volunteers were divided into two groups, (1) two-drop group, and (2) multiple-drop group. In the two-drop group, 15 volunteers randomly received two drops of 0.5% ketorolac tromethamine on one eye and two drops of 0.1% diclofenac sodium on the fellow eye. A masked investigator measured corneal sensation with the Cochet-Bonnet esthesiometer before applying the drops, and at 15, 30, and 60 minutes after using the eye drops. In the multiple-drop group, another 15 volunteers were randomly administered one drop of 0.5% ketorolac tromethamine or 0.1% diclofenac sodium in each eye, and the procedure was repeated every 5 minutes for 20 minutes. Corneal sensation was measured before, and 0, 15, 30 and 60 minutes after applying the drops.

RESULTS

In the two-drop group, neither of the eye drops had any effect on corneal sensation when only two drops were applied. In the multiple-drop group, corneal sensation was significantly reduced after multiple drops (p < 0.05) and was subsequently effective for at least 1 hour.

CONCLUSION

Both 0.5% ketorolac and 0.1% diclofenac can significantly decrease corneal sensation in normal eyes when multiple drops are used.

摘要

背景

开展了一项随机双盲研究，以调查0.5%酮咯酸氨丁三醇（阿乐迈）和0.1%双氯芬酸钠（扶他林）对正常人角膜感觉的影响。

方法

30名正常志愿者被分为两组，（1）两滴组，（2）多滴组。在两滴组中，15名志愿者随机在一只眼睛滴入两滴0.5%酮咯酸氨丁三醇，在另一只眼睛滴入两滴0.1%双氯芬酸钠。一名掩蔽的研究者在滴眼药前以及滴眼药后15、30和60分钟，使用科谢-博内角膜知觉计测量角膜感觉。在多滴组中，另外15名志愿者每只眼睛随机滴入一滴0.5%酮咯酸氨丁三醇或0.1%双氯芬酸钠，每隔5分钟重复该操作，共进行20分钟。在滴眼药前以及滴眼药后0、15、30和60分钟测量角膜感觉。