Stragand J, Hagemann R F
Am J Physiol. 1977 Sep;233(3):E208-11. doi: 10.1152/ajpendo.1977.233.3.E208.
Recent studies have shown that the rate of colonic cell renewal can be altered through fasting and refeeding, which produces a marked depression and transient stimulation, respectively. In the present study, the role of physical versus nutritional stimulation in the colonic fasting-refeeding response and the renewal of the functional colonic compartment were evaluated via a nondestructive colonic ligation procedure. The results reported herein suggest that physical stimulation by lumenal factors is in part required to initiate the colonic hyperplasia seen after refeeding. Blood-borne nutritional factors, in the absence of physical stimulation, cannot alone stimulate colonic cell production. Additional evidence is presented which suggests that this physical stimulation may be manifested through the lumenal distension produced by the newly ingested food materials. The results are discussed from the viewpoint of influencing the functional colonic compartment and physiological capacity.
最近的研究表明，结肠细胞更新率可通过禁食和再喂养而改变，禁食和再喂养分别会导致结肠细胞更新率显著降低和短暂升高。在本研究中，通过非破坏性结肠结扎程序评估了物理刺激与营养刺激在结肠禁食-再喂养反应及功能性结肠区室更新中的作用。本文报道的结果表明，腔内因素引起的物理刺激是再喂养后出现结肠增生所部分必需的。在没有物理刺激的情况下，血源性营养因子不能单独刺激结肠细胞生成。此外还提供了证据表明，这种物理刺激可能通过新摄入食物材料产生的肠腔扩张表现出来。从影响功能性结肠区室和生理能力的角度对结果进行了讨论。
