Smith B R, Rinder H M
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520-8035, USA.
Semin Hematol. 1997 Apr;34(2):90-7.
In both normal and abnormal vascular biology, platelet-leukocyte-RBC-EC adhesive and functional interactions appear to play a significant role. The clinical hallmarks of the TTP/HUS syndromes, including prominent platelet aggregation and thrombi without prominent soluble coagulation system activation along with microangiopathic hemolysis, suggest that such interactions may help to bring a common theme of explanation to this disorder. However, a final unifying physiological pathway remains elusive.
在正常和异常血管生物学中，血小板-白细胞-红细胞-内皮细胞的黏附及功能相互作用似乎都起着重要作用。血栓性血小板减少性紫癜/溶血尿毒症综合征的临床特征，包括显著的血小板聚集和血栓形成，但无显著的可溶性凝血系统激活，同时伴有微血管病性溶血，这表明此类相互作用可能有助于为该疾病带来一个共同的解释主题。然而，最终统一的生理途径仍不明确。
