Point mutations in the ileal bile salt transporter cause leaks in the enterohepatic circulation leading to severe chronic diarrhea and malabsorption.
作者信息
Small D M
出版信息
J Clin Invest. 1997 Apr 15;99(8):1807-8. doi: 10.1172/JCI119345.
Abstract
摘要
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Point mutations in the ileal bile salt transporter cause leaks in the enterohepatic circulation leading to severe chronic diarrhea and malabsorption.回肠胆汁酸转运体中的点突变导致肠肝循环出现渗漏，进而引发严重的慢性腹泻和吸收不良。
J Clin Invest. 1997 Apr 15;99(8):1807-8. doi: 10.1172/JCI119345.
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本文引用的文献
1
Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).由回肠钠依赖性胆汁酸转运蛋白基因（SLC10A2）突变引起的原发性胆汁酸吸收不良。
J Clin Invest. 1997 Apr 15;99(8):1880-7. doi: 10.1172/JCI119355.
2
Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein.在回肠脂质结合蛋白的情况下，灵活性可能是结合特异性的一个决定因素。
Structure. 1996 Jul 15;4(7):785-800. doi: 10.1016/s0969-2126(96)00086-x.
3
Structural analysis based on state-space modeling.基于状态空间建模的结构分析。
Protein Sci. 1993 Mar;2(3):305-14. doi: 10.1002/pro.5560020302.
4
Intestinal bile acid absorption. Na(+)-dependent bile acid transport activity in rabbit small intestine correlates with the coexpression of an integral 93-kDa and a peripheral 14-kDa bile acid-binding membrane protein along the duodenum-ileum axis.肠道胆汁酸吸收。兔小肠中依赖钠离子的胆汁酸转运活性与十二指肠-回肠轴上一种93 kDa整合型和一种14 kDa外周型胆汁酸结合膜蛋白的共表达相关。
J Biol Chem. 1993 Aug 25;268(24):18035-46.
5
Protein classification by stochastic modeling and optimal filtering of amino-acid sequences.通过氨基酸序列的随机建模和最优滤波进行蛋白质分类。
Math Biosci. 1994 Jan;119(1):35-75. doi: 10.1016/0025-5564(94)90004-3.
6
Bile acid transporters.
Curr Opin Lipidol. 1995 Apr;6(2):109-14. doi: 10.1097/00041433-199504000-00009.
7
Primary bile acid malabsorption: defective in vitro ileal active bile acid transport.原发性胆汁酸吸收不良：回肠胆汁酸体外主动转运存在缺陷。
Gastroenterology. 1982 Oct;83(4):804-11.
8
The enterohepatic circulation of bile salts.胆盐的肠肝循环。
Arch Intern Med. 1972 Oct;130(4):552-73.
9
Well-compensated primary bile acid malabsorption presenting as chronic nonspecific diarrhea.表现为慢性非特异性腹泻的代偿良好的原发性胆汁酸吸收不良
J Pediatr Gastroenterol Nutr. 1986 Jan;5(1):143-6. doi: 10.1097/00005176-198601000-00027.
10
Idiopathic bile acid catharsis.特发性胆汁酸腹泻
Gut. 1976 Dec;17(12):965-70. doi: 10.1136/gut.17.12.965.
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