Miller D P, Steinmetz J E
Department of Psychology, Carthage College, USA.
Behav Neurosci. 1997 Feb;111(1):70-9. doi: 10.1037//0735-7044.111.1.70.
Multiple-unit neuronal recordings were taken from the hippocampi of 10 male, New Zealand white rabbits during classical discrimination and reversal eyeblink conditioning using 2 tones as the conditioned stimuli (CS+ and CS-) and an air-puff unconditioned stimulus. During discrimination training, characteristic learning-related activity was seen in the hippocampus on trials when a conditioned response (CR) was executed. During early phases of reversal training, however, when high numbers of CRs were evident to both the new CS+ (the former CS-) and the new CS- (the former CS+), no learning-related activity was observed. Characteristic CR-related hippocampal activity to the CS+ was observed only after the rabbits began to learn the reversal response. These results suggest that the hippocampus may encode different features of eyeblink conditioning during discrimination and reversal learning.
在经典辨别和逆向眨眼条件反射过程中，对10只雄性新西兰白兔的海马体进行了多单元神经元记录。实验使用2种音调作为条件刺激（CS+和CS-）以及吹气作为非条件刺激。在辨别训练期间，当执行条件反应（CR）时，海马体中可观察到与学习相关的特征性活动。然而，在逆向训练的早期阶段，当对新的CS+（先前的CS-）和新的CS-（先前的CS+）都出现大量CR时，未观察到与学习相关的活动。仅在兔子开始学习逆向反应后，才观察到对CS+的与CR相关的海马体特征性活动。这些结果表明，海马体可能在辨别和逆向学习过程中编码眨眼条件反射的不同特征。
