Shteĭnberg G B, Zel'tser I Z, Balabanova E L, Churagulova N K, Mazitova O P
Antibiotiki. 1977 Sep;22(9):829-32.
For determination of the maximum permissible concentrations of antibiotics it is necessary to develop some specific approaches conditioned by the peculiarities of the biological effect of antibiotics in addition to the use of the general principles of the hygienic rationing of the factors of the production environment. It is advised to determine the thresholds of the specific antibacterial and allergen effect of antibiotics in the acute experiment in addition to the threshold of the general toxic effect.
为了确定抗生素的最大允许浓度，除了运用生产环境因素卫生定量的一般原则外，还必须根据抗生素生物效应的特点制定一些特定方法。建议在急性实验中除了确定抗生素的一般毒性作用阈值外，还要确定其特定抗菌和过敏原作用的阈值。
