González-Martin G, Maggio L, González-Sotomayor J, Zuniga S
Department of Pharmacy, Faculty of Chemistry, Catholic University of Chile, Santiago, Chile.
Int J Clin Pharmacol Ther. 1997 Apr;35(4):160-3.
The pharmacokinetics of 2 doses of intravenous ketorolac (0.5 and 0.9 mg x kg-1) were studied in 14 children (age 2-8 years). A single dose of the drug was injected into the dorsum vein of one hand. Blood samples were collected at regular time intervals for 6 hours. Serum ketorolac concentrations were assayed using a high pressure liquid chromatography method. Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume (Vdarea), the total clearance (Cltotal), and elimination half-life (t1/2 beta) were similar in both groups of children who either received 0.5 or 0.9 mg x kg-1 of ketorolac. The estimated geometric mean Vdarea, Cltotal, and t1/2 beta ratios (95% CI in parentheses) for 0.9 mg x kg-1:0.5 mg x kg-1 were 1.24 (0.82, 1.50), 1.14 (0.88, 1.23), and 1.083 (0.40, 1.81), respectively. The pharmacokinetic parameters found in this study are different from those found by other authors in adult subjects.
在14名2至8岁儿童中研究了2种剂量静脉注射酮咯酸（0.5和0.9毫克/千克）的药代动力学。将单剂量药物注入一只手的背部静脉。在6小时内定期采集血样。使用高压液相色谱法测定血清酮咯酸浓度。通过非线性计算机程序估算药代动力学值。接受0.5或0.9毫克/千克酮咯酸的两组儿童的分布容积（Vdarea）、总清除率（Cltotal）和消除半衰期（t1/2β）相似。0.9毫克/千克:0.5毫克/千克的估计几何平均Vdarea、Cltotal和t1/2β比值（括号内为95%置信区间）分别为1.24（0.82，1.50）、1.14（0.88，1.23）和1.083（0.40，1.81）。本研究中发现的药代动力学参数与其他作者在成人受试者中发现的不同。
