Noguchi S, Sata M, Suzuki H, Mizokami M, Tanikawa K
Second Department of Medicine, Kurume University School of Medicine, Japan.
Scand J Infect Dis. 1997;29(1):23-8. doi: 10.3109/00365549709008659.
We conducted an epidemiological study to investigate the routes of transmission of hepatitis C virus (HCV) infection in an area endemic for HCV. Subjects were the 857 adult inhabitants of K area, Japan. The prevalence of antibody to HCV (anti-HCV) was 26.3%. The HCV genotype 1b was the most prevalent (89.3%) among the anti-HCV positive subjects. Molecular evolutionary analysis, based on the nucleotide sequences of the HCV core region from 23 participants with type 1b, showed that the isolates were distributed into more than 1 group. Multivariate regression analysis demonstrated that an age over 40 years, a history of blood transfusion, the presence of antibody to hepatitis B core antigen (anti-HBc), or a history of surgery were each independently associated with the presence of anti-HCV. No significant differences in the presence of anti-HCV prevalence were observed between the wives of men positive for anti-HCV (33.3%) and age-matched women (36.4%), or between the husbands of women positive for anti-HCV (36.4%) and age-matched men (38.3%), from the same area. Findings suggest that the various strains of HCV type 1b were transmitted via medical procedures, not by the intrafamilial route.
我们开展了一项流行病学研究，以调查丙型肝炎病毒（HCV）地方性流行区域内HCV感染的传播途径。研究对象为日本K地区的857名成年居民。HCV抗体（抗-HCV）的流行率为26.3%。在抗-HCV阳性受试者中，HCV 1b型最为常见（89.3%）。基于23名1b型参与者的HCV核心区域核苷酸序列进行的分子进化分析表明，分离株分布于不止1个组。多变量回归分析显示，40岁以上的年龄、输血史、乙肝核心抗原抗体（抗-HBc）的存在或手术史均各自独立与抗-HCV的存在相关。在来自同一地区的抗-HCV阳性男性的妻子（33.3%）与年龄匹配的女性（36.4%）之间，以及抗-HCV阳性女性的丈夫（36.4%）与年龄匹配的男性（38.3%）之间，未观察到抗-HCV流行率存在显著差异。研究结果表明，HCV 1b型的各种毒株是通过医疗程序传播的，而非通过家庭内途径传播。
