Pawlak R, Chabielska E, Buczko W
Department of Pharmacodynamics, Medical Academy, Białystok, Poland.
Pol J Pharmacol. 1996 Jan-Feb;48(1):117-20.
The aim of the study was to investigate the potential antithrombotic action of enalapril in comparison with captopril after their acute and chronic administration in an experimental model of venous thrombosis in rats. Chronic treatment with captopril but not enalapril significantly reduced the incidence of venous thrombosis (67% vs 11%; p < 0.05). Both drugs markedly reduced the weight of thrombus. At the same time the platelet aggregation was reduced in rats acutely treated with both captopril and enalapril to 50 +/- 13% and 53 +/- 18%, respectively. The mean blood pressure dropped only after acute ACE-Is administration. No changes were observed in "transection" bleeding time. In conclusion, captopril and enalapril were able to inhibit the growth of thrombus in rats. Their antithrombotic effect seems to be independent from hypotensive action and influence on platelet aggregation.
本研究的目的是在大鼠静脉血栓形成的实验模型中，比较依那普利和卡托普利急性及慢性给药后的潜在抗血栓作用。卡托普利慢性治疗可显著降低静脉血栓形成的发生率（67%对11%；p<0.05），而依那普利则无此作用。两种药物均显著减轻血栓重量。同时，卡托普利和依那普利急性治疗的大鼠血小板聚集率分别降至50±13%和53±18%。仅在急性给予血管紧张素转换酶抑制剂后平均血压下降。“切断”出血时间未见变化。总之，卡托普利和依那普利能够抑制大鼠血栓的生长。它们的抗血栓作用似乎与降压作用及对血小板聚集的影响无关。
