Chabielska E, Pawlak R, Buczko W
Department of Pharmacodynamics, Medical Academy, Bialystok, Poland.
Pol J Pharmacol. 1996 Jan-Feb;48(1):89-91.
The aim of this study was to compare the potential antithrombotic action of captopril (angiotensin converting enzyme inhibitor) and losartan (a selective AT1 receptor antagonist) after their chronic administration in a model of venous thrombosis in rats. Captopril significantly reduced the incidence of venous thrombosis (67% vs 14%; p < 0.05) and both drugs markedly reduced the weight of thrombus. At the same time the platelet aggregation was reduced only in rats treated with losartan (100 +/- 7% vs 52 +/- 11%; p < 0.001). The mean blood pressure dropped only after losartan administration. We observed no changes in "transection" bleeding time after both drugs administration. In conclusion, captopril and losartan exerted an antithrombotic effect in venous thrombosis model in rats. The precise mechanism of this action should be established.
本研究的目的是比较卡托普利（一种血管紧张素转换酶抑制剂）和氯沙坦（一种选择性AT1受体拮抗剂）在大鼠静脉血栓形成模型中长期给药后的潜在抗血栓形成作用。卡托普利显著降低了静脉血栓形成的发生率（67%对14%；p<0.05），且两种药物均显著降低了血栓重量。同时，仅氯沙坦治疗的大鼠血小板聚集率降低（100±7%对52±11%；p<0.001）。仅在给予氯沙坦后平均血压下降。两种药物给药后，我们未观察到“切断”出血时间有变化。总之，卡托普利和氯沙坦在大鼠静脉血栓形成模型中发挥了抗血栓形成作用。应确定这种作用的确切机制。
