Kowalski J, Herman Z S
Department of Clinical Pharmacology, Silesian Academy of Medicine, Katowice, Poland.
Pol J Pharmacol. 1996 May-Jun;48(3):281-5.
Patients suffering from cancer (responsive to chemotherapy) are usually treated with a combination of anticancer drugs. In our previous studies, we found that captopril exerted antitumor action on Lewis lung carcinoma (LLC) in mice. This prompted us to evaluate the antitumor effect of captopril combined with cyclophosphamide. BD1F1 mice with LLC received two injections of captopril (5 mg/mouse) at a 1 h interval. Two hours later they were injected with cyclophosphamide (6 mg/mouse). Captopril pretreatment augmented the antitumor action of cyclophosphamide expressed as the survival time and the number of cured mice. Captopril given for five days before cyclophosphamide treatment did not change the antitumor activity of cyclophosphamide.
患有癌症（对化疗有反应）的患者通常采用抗癌药物联合治疗。在我们之前的研究中，我们发现卡托普利对小鼠Lewis肺癌（LLC）具有抗肿瘤作用。这促使我们评估卡托普利与环磷酰胺联合使用的抗肿瘤效果。患有LLC的BD1F1小鼠每隔1小时接受两次卡托普利注射（5毫克/只小鼠）。两小时后，它们被注射环磷酰胺（6毫克/只小鼠）。卡托普利预处理增强了环磷酰胺以生存时间和治愈小鼠数量表示的抗肿瘤作用。在环磷酰胺治疗前五天给予卡托普利并没有改变环磷酰胺的抗肿瘤活性。
