Anxiolytic-like effects of metabotropic glutamate antagonist (RS)-alpha-methylserine-O-phosphate in rats.
作者信息
Chojnacka-Wójcik E, Tatarczyńska E, Pilc A
机构信息
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
出版信息
Pol J Pharmacol. 1996 Sep-Oct;48(5):507-9.
PMID:9112693
Abstract
Using the conflict drinking Vogel test in rats as a model we examined the anxiolytic-like activity of (RS)-alpha-methylserine-O-phosphate (MSOP) and (RS)-alpha-methylserine-O-phosphate-monophenyl ester (MSOPPE), the antagonists of group III and II of mGluR, respectively, after their intrahippocampal administration. The results indicated that MSOP produced a dose dependent anticonflict effect in rats.
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