Pérez S, Pérez R M, Pérez C, Zavala M A, Vargas R
Universidad Autónoma Metropolitana-Xochimilco, México D.F., Mexico.
Pharm Acta Helv. 1997 Apr;72(2):105-11. doi: 10.1016/s0031-6865(96)00019-2.
From the methanol extract of the Arocomia mexicana root a new tetrahydropyrane compound was isolated. Its skeletal structure and relative stereochemistry were established by spectral analysis. Substituent effects have been determined with the hope of providing information about steric interactions and conformation of tetrahydropyran derivatives and carbohydrates. The extract showed a significant blood sugar lowering effect on normal and alloxan-diabetic mice when administered at 2.5 to 40 mg/kg i.p. doses, and exhibited a dose-dependent response in the mice models.
从墨西哥香豆根的甲醇提取物中分离出一种新的四氢吡喃化合物。通过光谱分析确定了其骨架结构和相对立体化学。已确定取代基效应，以期提供有关四氢吡喃衍生物和碳水化合物的空间相互作用和构象的信息。当以2.5至40mg/kg腹腔注射剂量给药时，该提取物对正常小鼠和四氧嘧啶糖尿病小鼠显示出显著的降血糖作用，并且在小鼠模型中表现出剂量依赖性反应。
