Hegyalijai T, Meienberg O, Dubler B, Gasser P
University Eye Clinic, Basel, Switzerland.
Angiology. 1997 Apr;48(4):345-9. doi: 10.1177/000331979704800407.
In order to learn the prevalence of cold-induced vasospasm in migraine patients, blood cell velocity measurements of finger nailfold capillaries were performed in 58 consecutive patients suffering from migraine with and without aura. In 5 (8.6%) patients capillaroscopy could not be performed because of reduced nailfold transparency; 21 of the remaining 53 patients (39.6%) showed blood flow stop due to vasospasm under cold provocation. There was no significant difference (P = 0.69) in the occurrence of vasospastic reaction between migraine with (12 of 32 patients = 37.5%) and without (9 of 21 patients = 42.9%) aura. The clinical and capillaroscopic course under migraine prophylaxis was observed in 18 vasospastic patients. After sixteen weeks 14 patients showed good clinical improvement of their migraine. The vasospastic reaction persisted in only 1 patient. This patient and 3 others with abolished vasospasm were still suffering from migraine. These findings suggest that observing blood cell velocity noninvasively in nailfold capillaries under cold provocation could be useful for objectively monitoring the response to prophylactic treatment in migraine patients or for testing new potentially antimigraine drugs.
为了解偏头痛患者中冷诱导血管痉挛的患病率，对58例连续的有先兆和无先兆偏头痛患者进行了甲襞毛细血管血细胞速度测量。5例（8.6%）患者因甲襞透明度降低无法进行毛细血管镜检查；其余53例患者中有21例（39.6%）在冷刺激下因血管痉挛出现血流停滞。有先兆偏头痛患者（32例中的12例 = 37.5%）和无先兆偏头痛患者（21例中的9例 = 42.9%）之间血管痉挛反应的发生率无显著差异（P = 0.69）。对18例血管痉挛患者在偏头痛预防性治疗期间的临床和毛细血管镜检查过程进行了观察。16周后，14例患者的偏头痛临床症状有明显改善。只有1例患者仍存在血管痉挛反应。该患者和另外3例血管痉挛已消除的患者仍患有偏头痛。这些发现表明，在冷刺激下无创观察甲襞毛细血管中的血细胞速度，可能有助于客观监测偏头痛患者对预防性治疗的反应或测试新的潜在抗偏头痛药物。
