Blechschmidt Tilo, Krumsiek Maike, Todorova Margarita G
Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH-4031 Basel, Switzerland.
EPMA J. 2017 May 31;8(2):177-185. doi: 10.1007/s13167-017-0096-4. eCollection 2017 Jun.
Patients with inherited diseases of the retina (IRD) often exhibit signs and symptoms of Flammer syndrome (FS). Acupuncture treatment has shown its positive effect on visual function in patients with IRD. The aim of the present study is to examine the effect of acupuncture on signs and symptoms of FS in a cohort of patients suffering simultaneously FS and IRD.
A prospective pilot study was performed on 17 patients with FS and IRD: rod-cone dystrophy, Nr: 12 (RCD); cone-rod dystrophy, Nr: 3 (CRD) and inherited macular dystrophy, Nr: 2 (IMD; 12♀, 5♂; mean age: 44.19 y; SD ±17.09 y). Acupuncture treatment was done applying needle acupuncture of the body and the ears. The treatment was scheduled at 10 half-hour sessions over 5 weeks. Primary outcome was evaluation of the post-acupuncture effect on the signs and symptoms of FS in IRD patients using multiple-choice questionnaires.
Following acupuncture, we found improvement in signs and symptoms of FS in patients suffering simultaneously IRD, as for instance (Nr. patients: improvement/suffering/total): a reduced tiredness (10/11/17), shorter sleep onset time (10/11/17), warmer feet and hands (10/10/17) and reduced frequency of headache attacks (9/11/17). Surprisingly, in four RCD patients and in one IMD patient, a reduction of macular edema was documented.
The applied acupuncture protocol for FS in IRD patients showed improvement in FS signs and symptoms and was tolerated well. Nevertheless, the objective evaluation of this complementary therapy on FS in IRD patients remains to be elucidated.
患有遗传性视网膜疾病(IRD)的患者常表现出弗拉默综合征(FS)的体征和症状。针灸治疗已显示出对IRD患者视觉功能的积极作用。本研究的目的是在同时患有FS和IRD的患者队列中,研究针灸对FS体征和症状的影响。
对17例患有FS和IRD的患者进行了一项前瞻性试点研究:视网膜色素变性,共12例(RCD);锥杆营养不良,共3例(CRD);遗传性黄斑营养不良,共2例(IMD;12例女性,5例男性;平均年龄:44.19岁;标准差±17.09岁)。采用体针和耳针进行针灸治疗。治疗安排在5周内进行10次半小时的疗程。主要结局是使用多项选择题问卷评估针灸后对IRD患者FS体征和症状的影响。
针灸后,我们发现同时患有IRD的患者的FS体征和症状有所改善,例如(患者数量:改善/患病/总数):疲劳减轻(10/11/17)、入睡时间缩短(10/11/17)、手脚变暖(10/10/17)以及头痛发作频率降低(9/11/17)。令人惊讶的是,在4例RCD患者和1例IMD患者中,记录到黄斑水肿减轻。
在IRD患者中应用的FS针灸方案显示出FS体征和症状有所改善,且耐受性良好。然而,这种补充疗法对IRD患者FS的客观评估仍有待阐明。