Hagger R, Finlayson C, Jeffrey I, Kumar D
Department of Surgery, St George's Hospital, London, UK.
Br J Surg. 1997 Apr;84(4):445-50.
The interstitial cells of Cajal (ICCs) are a population of cells in the gastrointestinal tract which have a role in the control of gut motility.
A comprehensive review of the scientific literature was undertaken to assess current understanding of the morphology, structure, identification, distribution, development and function of these cells.
ICCs have an important role in the control of gut motility. Experimental evidence from animal studies suggests roles as pacemakers and coordinators of gut motor activity, and as intermediaries in the neural control of motility. With an increasing understanding of the distribution and behaviour of these cells in the healthy or diseased human gastrointestinal tract, there is the potential to develop novel therapeutic approaches to diseases that have gut dysmotility as a contributory factor.
Cajal间质细胞（ICCs）是胃肠道中的一类细胞，在肠道运动控制中发挥作用。
对科学文献进行全面综述，以评估目前对这些细胞的形态、结构、识别、分布、发育和功能的理解。
ICCs在肠道运动控制中起重要作用。动物研究的实验证据表明，它们作为肠道运动活动的起搏器和协调者，以及运动神经控制的中介。随着对这些细胞在健康或患病人类胃肠道中的分布和行为的认识不断增加，有可能开发出针对以肠道运动障碍为促成因素的疾病的新型治疗方法。
