Farrugia G
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Annu Rev Physiol. 1999;61:45-84. doi: 10.1146/annurev.physiol.61.1.45.
Ion channels are the unitary elements that underlie electrical activity of gastrointestinal smooth muscle cells and of interstitial cells of Cajal. The result of ion channel activity in the gastrointestinal smooth muscle layers is a rhythmic change in membrane potential that in turn underlies events leading to organized motility patterns. Gastrointestinal smooth muscle cells and interstitial cells of Cajal express a wide variety of ion channels that are tightly regulated. This review summarizes 20 years of data obtained from patch-clamp studies on gastrointestinal smooth muscle cells and interstitial cells, with a focus on regulation.
离子通道是构成胃肠平滑肌细胞和 Cajal 间质细胞电活动的基本单元。胃肠平滑肌层中离子通道活动的结果是膜电位的节律性变化，而这种变化反过来又是导致有组织的运动模式的基础。胃肠平滑肌细胞和 Cajal 间质细胞表达多种受到严格调控的离子通道。本综述总结了 20 年来通过膜片钳研究获得的关于胃肠平滑肌细胞和间质细胞的数据，重点是调控方面。
