Pérez-Santonja J J, Sakla H F, Gobbi F, Alió J L
Alicante Institute of Ophthalmology, University of Alicante School of Medicine, Spain.
J Cataract Refract Surg. 1997 Mar;23(2):177-83. doi: 10.1016/s0886-3350(97)80339-2.
To ascertain whether 193 nm excimer laser in situ keratomileusis (LASIK) to correct high myopia causes in vivo changes in the human corneal endothelium 3 and 6 months after surgery.
Alicante Institute of Ophthalmology, University of Alicante, Spain.
Preoperative and serial postoperative specular microscopy of the central corneal endothelium was done in 33 eyes of 19 patients (Group 1) with a mean age of 34.3 years +/- 10.6 (SD) (range 20 to 60 years) who had LASIK to correct myopia of between 8.25 and 18.50 diopters (D) (mean 11.90 +/- 2.20 D). Twelve patients (20 eyes) were contact lens wearers (Group 2), and 7 (13 eyes) had never worn contact lenses (Group 3). The central endothelium was analyzed for several parameters including cell density, coefficient of variation in cell size, and hexagonality. The data obtained before surgery were compared with those obtained after surgery in all groups.
There was no significant difference in age, sex, and preoperative myopia between Groups 2 and 3. In Group 1, mean cell density was significantly higher (3.5%) 6 months after surgery (P = .017) and the coefficient of variation decreased 3 and 6 months after surgery (P < .001); no significant changes were noted in the percentage of hexagonal cells. In Group 2, there was a significant increase in cell density (4.8%) 6 months after surgery (P = .010) and the coefficient of variation decreased at 3 and 6 months after surgery (P < .001); the hexagonality did not change postoperatively. In Group 3, there were no significant differences between preoperative and postoperative mean cell density, coefficient of variation, or hexagonality.
Laser in situ keratomileusis caused no damage to the central corneal endothelium. Postoperative improvements in the endothelial cell density and the coefficient of variation in cell size values were related to the discontinuance of contact lens use after surgery.
确定193纳米准分子激光原位角膜磨镶术（LASIK）矫正高度近视术后3个月和6个月时，人角膜内皮细胞在体内是否发生变化。
西班牙阿利坎特大学阿利坎特眼科研究所。
对19例患者（第1组）的33只眼进行术前及术后连续的中央角膜内皮细胞镜面反射显微镜检查，这些患者平均年龄34.3岁±10.6（标准差）（年龄范围20至60岁），接受LASIK矫正8.25至18.50屈光度（D）（平均11.90±2.20 D）的近视。12例患者（20只眼）为隐形眼镜佩戴者（第2组），7例（13只眼）从未佩戴过隐形眼镜（第3组）。分析中央内皮细胞的几个参数，包括细胞密度、细胞大小变异系数和六边形化程度。比较所有组术前和术后获得的数据。
第2组和第3组在年龄、性别和术前近视程度方面无显著差异。在第1组中，术后6个月平均细胞密度显著升高（3.5%）（P = 0.017），细胞大小变异系数在术后3个月和6个月降低（P < 0.001）；六边形细胞百分比无显著变化。在第2组中，术后6个月细胞密度显著增加（4.8%）（P = 0.01），细胞大小变异系数在术后3个月和6个月降低（P < 0.001）；术后六边形化程度未改变。在第3组中，术前和术后平均细胞密度、细胞大小变异系数或六边形化程度无显著差异。
准分子激光原位角膜磨镶术未对中央角膜内皮细胞造成损伤。术后内皮细胞密度和细胞大小变异系数值的改善与术后停止使用隐形眼镜有关。
