Chiang Chun-Chi, Lin Jane-Ming, Bair Pei-Jane, Chen Wen-Lu, Tseng Sung-Huei, Tsai Yi-Yu
Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan.
Kaohsiung J Med Sci. 2005 Jun;21(6):272-6. doi: 10.1016/S1607-551X(09)70200-1.
The purpose of this study was to assess the effects of laser in situ keratomileusis (LASIK) on the corneal endothelium. In a prospective study, the corneal endothelium of 87 eyes (45 patients) was examined before and 1 month after LASIK. Patients were divided into two groups: people who wear contact lenses (48 eyes) and people who had never worn contact lenses (39 eyes). The corneal endothelium was analyzed for cell density, percentage of hexagonal cells, and coefficient of variation (CV) of cell size. The mean cell density and percentage of hexagonal cells was significantly higher 1 month after LASIK for all 87 eyes. However, the mean CV of cell size was not significantly different. In contact lens wearers, there was a significant increase in mean cell density and percentage of hexagonal cells, but there was no significant change in mean CV of cell size after LASIK. Among patients who had never worn contact lenses, no significant changes were noted in mean cell density, percentage of hexagonal cells, or mean CV of cell size. In this study, LASIK caused no damage to the corneal endothelium. Postoperative improvements in the mean cell density and percentage of hexagonal cells in patients who were contact lens wearers may be related to the discontinuance of contact lens use after LASIK.
本研究的目的是评估准分子激光原位角膜磨镶术（LASIK）对角膜内皮的影响。在一项前瞻性研究中，对87只眼（45例患者）在LASIK术前及术后1个月进行角膜内皮检查。患者分为两组：戴隐形眼镜者（48只眼）和从未戴过隐形眼镜者（39只眼）。分析角膜内皮的细胞密度、六角形细胞百分比及细胞大小变异系数（CV）。所有87只眼在LASIK术后1个月时平均细胞密度和六角形细胞百分比显著升高。然而，细胞大小的平均CV无显著差异。在戴隐形眼镜者中，LASIK术后平均细胞密度和六角形细胞百分比显著增加，但细胞大小的平均CV无显著变化。在从未戴过隐形眼镜的患者中，平均细胞密度、六角形细胞百分比或细胞大小的平均CV均无显著变化。在本研究中，LASIK未对角膜内皮造成损伤。戴隐形眼镜患者术后平均细胞密度和六角形细胞百分比的改善可能与LASIK术后停止使用隐形眼镜有关。
