Geldmacher D S
Cerebrovascular Center, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
Neurosurg Clin N Am. 1997 Apr;8(2):245-51.
Despite the intense efforts devoted to preventing and aborting cerebral ischemia, some individuals will continue to have completed infarctions. Failure of prevention or intervention does not, however, preclude therapeutic approaches to enhance recovery. This article will review working definitions applicable to the care and rehabilitation of patients after ischemic stroke. Significant, preliminary research on how adrenergic systems may alter the recovery from cerebral damage is also reviewed. Beneficial effects of agents which promote adrenergic function, and the adverse effects of monoaminergic blockade in animals and humans are discussed. The potential role of synaptic mechanisms like long-term potentiation is reviewed in the context of motor recovery. These factors are likely to have important implications in the future acute care of patients with completed stroke.
尽管人们为预防和终止脑缺血付出了巨大努力，但仍有一些人会出现完全性梗死。然而，预防或干预的失败并不排除采取促进恢复的治疗方法。本文将回顾适用于缺血性中风患者护理和康复的实用定义。还将回顾关于肾上腺素能系统如何改变脑损伤恢复的重要初步研究。讨论了促进肾上腺素能功能的药物的有益作用以及单胺能阻断在动物和人类中的不良反应。在运动恢复的背景下，回顾了诸如长时程增强等突触机制的潜在作用。这些因素可能对未来完全性中风患者的急性护理具有重要意义。
