Carlson L A, Danielson M, Ekberg I, Klintemar B, Rosenhamer G
Atherosclerosis. 1977 Sep;28(1):81-6. doi: 10.1016/0021-9150(77)90201-5.
In an ongoing study 558 consecutive survivors of myocardial infarction below 70 years, mean age 59 years, were randomly allocated 4 months after the acute episode into a control group or a chemotherapy group from December 1972 to April 1976. Both groups were given moderate advice about diet and the chemotherapy group was prescribed clofibrate, 1 g twice daily, and nicotinic acid 1 g three times daily. Serum cholesterol and triglycerides were lowered around 15-20% and 30% respectively in the chemotherapy group while only insignificant reductions were observed in the control group. Until December 1976 total mortality and mortality from IHD has been the same in the two groups. The number of non-fatal myocardial infarctions has been 38 in the control and 19 in the chemotherapy group, a statistically significant reduction (P less than 0.01).
在一项正在进行的研究中，558名年龄在70岁以下的心肌梗死连续幸存者，平均年龄59岁，于1972年12月至1976年4月急性发作4个月后被随机分为对照组或化疗组。两组均接受了适度的饮食建议，化疗组被开了氯贝丁酯，每日两次，每次1克，以及烟酸，每日三次，每次1克。化疗组的血清胆固醇和甘油三酯分别降低了约15 - 20%和30%，而对照组仅观察到微不足道的降低。直到1976年12月，两组的总死亡率和缺血性心脏病死亡率相同。对照组非致命性心肌梗死的数量为38例，化疗组为19例，有统计学意义的降低（P小于0.01）。
