Asimakopoulos G, Barlow C, Pillai R
Department of Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, UK.
Postgrad Med J. 1998 Mar;74(869):157-60. doi: 10.1136/pgmj.74.869.157.
The recently published Scandinavian Simvastatin Survival Study showed that long-term treatment with simvastatin, in patients with ischaemic heart disease and serum cholesterol levels between 5.5 and 8.0 mmol/l, improved survival. The present study was conducted in order to evaluate whether patients with ischaemic heart disease awaiting coronary revascularisation are aware of their serum cholesterol levels and whether raised levels are being treated adequately. One hundred consecutive patients admitted from our waiting list for elective coronary artery bypass grafting, with or without valve replacement, were included in the study. The patients were asked whether they had a history of raised serum cholesterol and, if so, how this was being treated. Fasting serum cholesterol levels were subsequently taken in the morning before surgery. Forty-six patients gave a positive history of raised blood cholesterol levels; 25 of these were on cholesterol-lowering medication at the time of admission, 15 were on a lipid-lowering diet and six were not being treated. Thirty-one (67%) of these 46 patients had a serum cholesterol of more than 5.5 mmol/l, compared with 30 (56%) of the 54 patients without a positive history of hypercholesterolaemia, and 61% of the total 100 patients. These data suggest that an inadequate number of patients awaiting coronary artery bypass grafting are aware of their cholesterol status. The management of hypercholesterolaemia among these patients could be improved.
最近发表的斯堪的纳维亚辛伐他汀生存研究表明,对于缺血性心脏病且血清胆固醇水平在5.5至8.0毫摩尔/升之间的患者,长期使用辛伐他汀治疗可提高生存率。本研究旨在评估等待冠状动脉血运重建的缺血性心脏病患者是否知晓自己的血清胆固醇水平,以及升高的水平是否得到了充分治疗。本研究纳入了100例连续从我们的择期冠状动脉旁路移植术等候名单中入院的患者,这些患者接受或未接受瓣膜置换术。询问患者是否有血清胆固醇升高的病史,若有,是如何治疗的。随后在手术前的早晨采集空腹血清胆固醇水平。46例患者有血清胆固醇升高的阳性病史;其中25例在入院时正在服用降胆固醇药物,15例采用低脂饮食,6例未接受治疗。这46例患者中有31例(67%)血清胆固醇超过5.5毫摩尔/升,而54例无高胆固醇血症阳性病史的患者中有30例(56%),100例患者总数中有61%。这些数据表明,等待冠状动脉旁路移植术的患者中知晓自己胆固醇状况的人数不足。这些患者中高胆固醇血症的管理有待改善。