Leptin expression and action: new experimental paradigms.
作者信息
Flier J S
机构信息
Division of Endocrinology, Beth Israel Deaconess Medical Center, Research North, 99 Brookline Avenue, Boston, MA 02215, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4242-5. doi: 10.1073/pnas.94.9.4242.
Abstract
摘要
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本文引用的文献
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Localization of a "feeding center" in the hypothalamus of the rat.大鼠下丘脑“摄食中枢”的定位
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2
Direct antidiabetic effect of leptin through triglyceride depletion of tissues.瘦素通过组织甘油三酯消耗产生的直接抗糖尿病作用。
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4637-41. doi: 10.1073/pnas.94.9.4637.
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Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes.通过皮下植入的3T3-F442A前脂肪细胞来源的脂肪垫在体内水平表达肥胖基因。
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4300-5. doi: 10.1073/pnas.94.9.4300.
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The leptin receptor.
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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.解偶联蛋白-2：一种与肥胖和高胰岛素血症相关的新基因。
Nat Genet. 1997 Mar;15(3):269-72. doi: 10.1038/ng0397-269.
6
Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.CCAAT/增强子结合蛋白α与过氧化物酶体增殖物激活受体γ在瘦素启动子上的功能拮抗作用。
J Biol Chem. 1997 Feb 21;272(8):5283-90. doi: 10.1074/jbc.272.8.5283.
7
Diet-induced obese mice develop peripheral, but not central, resistance to leptin.饮食诱导的肥胖小鼠会出现外周而非中枢对瘦素的抵抗。
J Clin Invest. 1997 Feb 1;99(3):385-90. doi: 10.1172/JCI119171.
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Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue.瘦素和解偶联蛋白在白色和棕色脂肪组织中的免疫组织化学定位
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