Park C S, Müller N L, Worthy S A, Kim J S, Awadh N, Fitzgerald M
Department of Radiology, University of British Columbia and Vancouver Hospital and Health Sciences Centre, Canada.
Radiology. 1997 May;203(2):361-7. doi: 10.1148/radiology.203.2.9114089.
To determine differences in computed tomographic (CT) findings in asthmatic and healthy individuals and to correlate the findings with severity of airway obstruction.
Thirty-nine asthmatic patients and 14 healthy subjects were prospectively evaluated with thin-section CT. Inspiratory CT scans were subjectively evaluated for presence of bronchial wall thickening, bronchial dilatation, and mosaic lung attenuation; expiratory scans were subjectively evaluated for presence of air trapping. Objective measurement of bronchoarterial-diameter ratio was performed on inspiratory scans. CT findings were compared with pulmonary function test results.
Bronchial wall thickening, severe air trapping, and reduced bronchoarterial-diameter ratio were observed more commonly in asthmatic patients than in healthy subjects. Bronchial wall thickening was more prevalent among patients with severe airflow obstruction (10 of 12 readings [83%]) than in patients with normal airflow (15 of 40 readings [38%]) or mild obstruction (nine of 26 readings [35%]). Other subjectively determined CT findings did not correlate with pulmonary function test results. The mean bronchoarterial-diameter ratios +/- 1 standard deviation were 0.65 +/- 0.16 in healthy subjects and 0.60 +/- 0.16, 0.60 +/- 0.18, and 0.48 +/- 0.11 in patients with normal airflow and mild and severe obstruction, respectively.
Thin-section CT is of limited value in distinguishing asthmatic patients with normal airflow or mild airflow obstruction from healthy subjects.
确定哮喘患者与健康个体在计算机断层扫描（CT）结果上的差异，并将这些结果与气道阻塞的严重程度相关联。
对39例哮喘患者和14名健康受试者进行前瞻性薄层CT评估。对吸气期CT扫描主观评估支气管壁增厚、支气管扩张和肺马赛克样衰减的情况；对呼气期扫描主观评估空气潴留情况。在吸气期扫描上对支气管动脉直径比进行客观测量。将CT结果与肺功能测试结果进行比较。
与健康受试者相比，哮喘患者中更常见支气管壁增厚、严重空气潴留和支气管动脉直径比降低。支气管壁增厚在严重气流阻塞患者中更为普遍（12次读数中有10次[83%]），高于气流正常患者（40次读数中有15次[38%]）或轻度阻塞患者（26次读数中有9次[35%]）。其他主观判断的CT结果与肺功能测试结果无关。健康受试者的平均支气管动脉直径比±1标准差为0.65±0.16，气流正常、轻度阻塞和严重阻塞患者分别为0.60±0.16、0.60±0.18和0.48±0.11。
薄层CT在区分气流正常或轻度气流阻塞的哮喘患者与健康受试者方面价值有限。
