Chapman S, Cohen P R
Department of Internal Medicine, University of Texas-Houston Medical School 77030, USA.
South Med J. 1997 Apr;90(4):395-8. doi: 10.1097/00007611-199704000-00006.
Transverse white nail banding can be inherited or caused by a variety of diseases and medications, including cancer chemotherapeutic agents. We report three cases in which patients with cancer had antineoplastic therapy-induced transverse leukonychia and summarize previously published reports. There is no specific cancer chemotherapeutic drug, combination of drugs, or drug class that causes transverse leukonychia; however, cyclophosphamide, doxorubicin, and vincristine are the therapeutic agents most frequently involved. For patients receiving cancer chemotherapy, white transverse nail banding is a side effect of the medication rather than a consequence of underlying malignancy.
