信号转导：抑制Src活性。
Signal transduction: clamping down on Src activity.
作者信息
Mayer B J
机构信息
Howard Hughes Medical Institute, Children's Hospital, Department of Microbiology and Molecular Genetics, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA.
出版信息
Curr Biol. 1997 May 1;7(5):R295-8. doi: 10.1016/s0960-9822(06)00141-2.
PMID:9115388
Abstract
Recent high-resolution structures of members of the Src family of protein-tyrosine kinases illustrate how a series of cooperative intramolecular interactions represses the catalytic activity of these kinases, but allows for their rapid activation by a variety of regulatory inputs.
摘要
近期蛋白质酪氨酸激酶Src家族成员的高分辨率结构表明，一系列协同的分子内相互作用如何抑制这些激酶的催化活性，但又允许它们通过多种调节输入实现快速激活。
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