Rowles A, Blow J J
Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3LD, UK.
Curr Opin Genet Dev. 1997 Apr;7(2):152-7. doi: 10.1016/s0959-437x(97)80123-2.
Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chromatin during G1 to define a prereplicative complex. During S phase, these proteins are displaced from chromatin and their reassembly is inhibited by protein-dependent kinases.
真核生物DNA复制至少部分受起始蛋白组装到复制起点的调控。在细胞周期的大部分时间里，起始识别复合物（ORC）都与复制起点结合。其他起始蛋白，如Cdc6和MCM/P1蛋白，在G1期组装到含有ORC的染色质上，以形成前复制复合物。在S期，这些蛋白从染色质上被置换下来，并且它们的重新组装受到蛋白依赖性激酶的抑制。
