Wickens M, Anderson P, Jackson R J
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA.
Curr Opin Genet Dev. 1997 Apr;7(2):220-32. doi: 10.1016/s0959-437x(97)80132-3.
The cytoplasmic life of an mRNA revolves around the regulation of its localization, translation and stability. Interactions between the two ends of the mRNA may integrate translation and mRNA turnover. Regulatory elements in the region between the termination codon and poly(A) tail - the 3' untranslated region - have been identified in a wide variety of systems, as have been some of the key players with which these elements interact.
信使核糖核酸（mRNA）的胞质生命围绕其定位、翻译和稳定性的调控展开。mRNA两端之间的相互作用可能整合翻译和mRNA周转。在终止密码子和多聚腺苷酸（poly(A)）尾之间的区域——3'非翻译区——中的调控元件已在多种系统中得到鉴定，与这些元件相互作用的一些关键因子也是如此。
