Lanouette J M, Duquette D A, Jacques S M, Qureshi F, Johnson M P, Berry S M
Division of Maternal Fetal Medicine, Wayne State University/Hutzel Hospital, Detroit MI 48201-1498, USA.
Fetal Diagn Ther. 1996 Nov-Dec;11(6):414-6. doi: 10.1159/000264357.
Intrauterine infection with herpes simplex virus (HSV) has been associated with a significant number of neonatal HSV infections. When these infections begin in utero, the associated morbidity is more severe, and treatment regimens may be less effective.
A 24-year-old nullipara with an abnormal triple screen and multiple ultrasound abnormalities at 19 weeks' gestation underwent amniocentesis and cordocentesis. Laboratory results were consistent with HSV infection. The patient elected to terminate the pregnancy, and on postmortem examination of the fetus, evidence of disseminated disease was present.
We believe that this case documents a relationship between HSV infection and findings on ultrasound that have previously been described in association with other in utero infections. We suggest that general viral cultures of the amniotic fluid be done when in utero infection is suspected.
子宫内单纯疱疹病毒（HSV）感染与大量新生儿HSV感染相关。当这些感染在子宫内开始时，相关的发病率更高，且治疗方案可能效果较差。
一名24岁未产妇，孕19周时三联筛查异常且多次超声检查有异常，接受了羊膜腔穿刺术和脐静脉穿刺术。实验室检查结果与HSV感染相符。患者选择终止妊娠，对胎儿进行尸检时发现有播散性疾病的证据。
我们认为该病例证明了HSV感染与先前已描述的与其他子宫内感染相关的超声检查结果之间的关系。我们建议，当怀疑有子宫内感染时，应进行羊水的常规病毒培养。
